The laws governing the legal use, storage and carrying of firearms are constantly changing. Below are the applicable laws in the State of New York as of 2/13/2013. The below information is designed to be a guide and not the final word. If you have specific questions, please refer to  the State of Pennsylvania legislation at legis.state.pa.us. Another great source is the Pennsylvania Firearm Owners Association and can be found at pafoa.org.

§6109.Purpose of license
A license to carry a firearm shall be for the purpose of carrying a firearm concealed on or about one's person or in a vehicle throughout this Commonwealth.
A person who is otherwise eligible to possess a valid license under this chapter but carries a firearm in any vehicle or any person who carries a firearm concealed on or about his person, except in his place of abode or fixed place of business, without a valid and lawfully issued license and has not committed any other criminal violation commits a misdemeanor of the first degree.

18 Pa.C.S.A. § 6106 Firearms not to be Carried Without a License
(1) Except as provided in paragraph (2), any person who carries a firearm in any vehicle or any person who carries a firearm concealed on or about his person, except in his place of abode or fixed place of business, without a valid and lawfully issued license under this chapter commits a felony of the third degree.
(2) A person who is otherwise eligible to possess a valid license under this chapter but carries a firearm in any vehicle or any person who carries a firearm concealed on or about his person, except in his place of abode or fixed place of business, without a valid and lawfully issued license and has not committed any other criminal violation commits a misdemeanor of the first degree.

 Exceptions.--The provisions of subsection (a) shall not apply to:
Any person while carrying a firearm in any vehicle, which person possesses a valid and lawfully issued license for that firearm which has been issued under the laws of the United States or any other state.
Any person who possesses a valid and lawfully issued license or permit to carry a firearm which has been issued under the laws of another state, regardless of whether a reciprocity agreement exists between the Commonwealth and the state under section 6109(k), provided:
(i) The state provides a reciprocal privilege for individuals licensed to carry firearms under section 6109.
(ii) The Attorney General has determined that the firearm laws of the state are similar to the firearm laws of this Commonwealth.

Federal Law: § 926A. Interstate Transportation of Firearms
Notwithstanding any other provision of any law or any rule or regulation of a State or any political subdivision thereof, any person who is not otherwise prohibited by this chapter from transporting, shipping, or receiving a firearm shall be entitled to transport a firearm for any lawful purpose from any place where he may lawfully possess and carry such firearm to any other place where he may lawfully possess and carry such firearm if, during such transportation the firearm is unloaded, and neither the firearm nor any ammunition being transported is readily accessible or is directly accessible from the passenger compartment of such transporting vehicle: Provided, That in the case of a vehicle without a compartment separate from the driver’s compartment the firearm or ammunition shall be contained in a locked container other than the glove compartment or console.State Preemption

Note: No license is required:
1.to carry a firearm in one's home or fixed place of business.
2.when engaged in target shooting or while going to or from their places of assembly or target practice, so long as the firearm is unloaded and the ammunition is carried in a separate container.
3.for law enforcement personnel, including: policemen, jail wardens, sheriffs and their deputies.
4.to carry an unloaded and wrapped firearm from place of purchase to one's home or place of business, to or from a place of repair, "or in moving from one place of abode or business to another."
5.to carry while hunting or fishing or going to the place of hunting or fishing, provided one has a hunting or fishing license and a Sportsman's Firearm Permit.